Calcium Folinate

$91.00$1,546.15

Calcium folinate is the calcium salt of 5-formyl tetrahydrofolic acid. It is an active metabolite of folinic acid and an essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.


Looking for a different size?
We can supply custom sizes, contact us to discuss your needs.

Clear
SKU: N/A Category: Tags: ,

Description

Product Name: Calcium folinate
Synonym: Folinic acid calcium salt; calcium leucovorin
UNII: RPR1R4C0P4
CAS: 1492-18-8
Molecular Formula: C20H21CaN7O7
Molecular Weight: 511.50 g/mol
Appearance: White or light yellow,amorphous or crystalline, hygroscopic powder
Storage: Warehouse should be ventilation and low temperature, cool and dry;

What is Calcium folinate?

Calcium folinate is the calcium salt of 5-formyl tetrahydrofolic acid. It is an active metabolite of folinic acid and an essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.

Calcium folinate and folate antagonists share the same membrane transport carrier and compete for transport into cells, stimulating folate antagonist efflux. It also protects cells from the effects of folate antagonist by repletion of the reduce folate pool. Calcium folinate serves as a pre-reduced source of H4 folate; it can therefore bypass folate antagonist blockage and provide a source for the various coenzyme forms of folic acid.

Calcium folinate is also frequently used in the biochemical modulation of fluoropyridine (5-FU) to enhance its cytotoxic activity. 5-FU inhibits thymidylate synthase (TS), a key enzyme involved in pyrimidine biosynthesis, and calcium folinate enhances TS inhibition by increasing the intracellular folate pool, thus stabilising the 5FU-TS complex and increasing activity.

Finally, intravenous calcium folinate can be administered for the prevention and treatment of folate deficiency when it cannot be prevented or corrected by the administration of folic acid by the oral route. This may be the case during total parenteral nutrition and severe malabsorption disorders. It is also indicated for the treatment of megaloblastic anaemia due to folic acid deficiency, when oral administration is not feasible.

What is calcium folinate used for?

This medication is used to treat or prevent serious blood cell disorders (such as thrombocytopenia, neutropenia, anemia) caused by certain drugs (folic acid antagonists such as methotrexate, trimethoprim, pyrimethamine).

INDICATIONS AS AT 02 DECEMBER 2005: As rescue therapy to reduce toxicity following high dose methotrexate therapy. Has shown good results in the treatment of certain megaloblastic anaemias resulting from folic acid deficiency. This mainly occurs in infants, during pregnancy, in malabsorption syndromes, liver diseases, sprue and malnutrition. It is not more active than folic acid for these conditions. Overdosage of methotrexate and in impaired methotrexate elimination. Reducing the toxicity and circumventing the effects of folic acid antagonists.

Additional information

Size

50g, 100g, 250g, 500g, 750g, 1kg

Reviews

There are no reviews yet.

Be the first to review “Calcium Folinate”

Your email address will not be published. Required fields are marked *